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Title: Role of metalloproteins containing copper, zinc or iron in pathogenesis of organ changes in hypertension

Author:

Płatek, Joanna

Date:

2015

Type:

Praca doktorska

Abstract:

The aim of this study was to assess the relationship between plasma trace elements concentration (iron, copper and zinc), their 24-hour urinary excretion, plasma metalloprotein concentration (ferritin, ceruloplasmin) and blood pressure (BP) values, the prevalence of hypertension and indicators of cardiac and vascular organ damage typical for hypertension. The study group included 303 individuals, recruited from the general population (138 parents; 165 offspring, 136M/167F). In addition anthropometric measures, conventional BP measurements and 24-hour ambulatory BP monitoring, echocardiography, carotid ultrasonography and arterial applanation tonometry were provided. Iron, copper and zinc plasma concentration and 24-hour urinary excretion was assessed by ICP-MS (Inductively Coupled Plasma Mass Spectrometry). Selected metalloproteins of these metals (ferritin, ceruroplasmin) were determined by the ELISA test. Database management and statistical analysis were performed with SAS software (SAS Institute, Cary, NC), version 9.3. In this study the association of iron and copper homeostasis with blood pressure (BP) values and the association of three metals under study with vascular complications were shown. The results in the future may contribute to the further research into the pathogenesis of hypertension.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Stolarz-Skrzypek, Katarzyna ; Zapotoczny, Szczepan

Date issued:

2015

Identifier:

oai:dl.cm-uj.krakow.pl:4061

Call number:

ZB-124230

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

iron zinc organ damage copper hypertension

Object collections:

Last modified:

Mar 16, 2023

In our library since:

Apr 13, 2016

Number of object content hits:

3

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4061

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Edition name Date
ZB-124230 Mar 16, 2023

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