Object

Title: Effect of angiotensin converting enzyme inhibitors and statins on the expression of coagulation factors in the narrow aortic valves – associations with calcification, neovascularization and inflammation in aortic stenosis

Abstract:

This dissertation presents the effect of statins, angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker (ARB) on the expression of proteins associated with inflammation, calcification and coagulation cascade in vitro in VICs cultures. This study presents mRNA analysis of the gene expression associated with inflammation, calcification and osteoblastic transformation, coagulation proteins, PAR receptors and a neovascularization using Real-time PCR in three different aortic valve areas. In addition, the influence of statins: atorvastatin and rosuvastatin, ACEI: enalpril and ramipril, and ARB: candesartan, in different concentrations on the expression of proinflammatory cytokines, calcification and expression of coagulation proteins and PAR receptors in stimulated VICs was analyzed. This in vitro study increases knowledge about the effect of statins, ACEIs and ARB on proinflammatory response, calcification and expression of coagulation protein in AS.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; farmakologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Anetta Undas ; Zbigniew Adamczyk

Date issued:

2015

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4049

Call number:

ZB-123685

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Apr 8, 2016

Number of object content hits:

101

Number of object content views in PDF format

101

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4049

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-123685 May 24, 2021
×

Citation

Citation style:

This page uses 'cookies'. More information