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Title: Effects of cardiac resynchronisation therapy on the autonomic nervous system function, sleep disorders, and vascular stiffness

Abstract:

The aim of this study was simultaneous evaluation of CRT effects on the autonomic nervous system function, sleep disorders, arterial stiffness, depression level, as well as an assessment of their interactions, together with an analysis of a clinical response of all these parameters to CRT. The study covered 55 people with chronic heart failure stable for at least last 3 months, in the NYHA class III-IV despite optimal pharmacotherapy, with sinus rhythm present during the examination, a left ventricular ejection fraction (LVEF) ≤ 35%, wide QRS complexes ≥ 120 ms. In the whole group a statistically significant increase in the arterial baroreflex sensitivity (BRS) when lying and return their ability to modulate in response to orthostatic stimulus were observed. The values of apnea-hypopnea index, as well as central and mixed apnea indexes were statistically significantly reduced. A shift in dominance from central to obstructive sleep apnea was also observed. Beneficial effects of CRT were noted for subjective sleep parameters and depression level. Significant changes weren’t demonstrated for arterial stiffness. Negative correlations between changes of polysomnographic parameters, subjective sleep parameters and depression intensity with changes of BRS and LVEF were affirmed. The clinical improvement defined as an improvement by at least one NYHA class was connected with an improvement in polysomnographic parameters and subjective parameters evaluating sleep quality, daytime sleepiness and depression level, as well as with an improvement in the autonomic nervous system function and arterial stiffness.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Danuta Czarnecka

Date issued:

2015

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4038

Call number:

ZB-123739

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Feb 1, 2016

Number of object content hits:

10

Number of object content views in PDF format

10

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4038

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ZB-123739 Jun 26, 2019
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