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Title: Early detection of the increased risk of cardiovasculartoxicity in patients undergoing anthracycline-based CHOPregimen

Author:

Długosz-Danecka, Monika

Date:

2015

Type:

Praca doktorska

Abstract:

One of the most commonly used first line regimens is CHOP protocol.It’s efficacy depends largely from doxorubicin: an anthracyclineantibiotic, responsible for marked cardiovascular toxicity. Clinicalsymptoms of doxorubicin cardiotoxicity occur late in the diseasecourse. At this stage however, the process is already non-reversible.Early diagnosis, before the eventual damage of cardiomyocytes,possible by demonstrating diastolic dysfunction, allows introducingefficient cardioprotective therapy preventing further cardiac damage.Primary and secondary targets of the work were: early identification ofpatients with high-risk of cardiotoxicity and analysis of primaryeffectiveness of cardioprotective strategies (non-pegylated liposomaldoxorubicin, cardioprotective drugs) in high risk patients. Presenteddata are consistent: NT-proBNP, spatial QRS-T angle analysis andechocardiographic assessment of diastolic dysfunction of the leftventricle allow for early detection of doxorubicin cardiotoxicity, at thereversible stage, allowing for efficient prophylaxis before irreversiblecardiomyocyte damage occurs. Primary cardioprotection withliposomal doxorubicin, in combination with the beta-adrenolytic drugsand/or ACE-inhibitor allowed for effective oncological treatment ofpatients with increased cardiovascular risk, without development ofcardiotoxic complications.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia ; hematologia ; choroby układu krążenia ; farmakologia

Degree grantor:

Wydział Lekarski

Promoter:

Jurczak, Wojciech

Date issued:

2014

Identifier:

oai:dl.cm-uj.krakow.pl:4008

Call number:

ZB-122910

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

anthracyclines cardiotoxicity cardioprotection echocardiography CHOP

Object collections:

Last modified:

Mar 14, 2023

In our library since:

Jul 1, 2015

Number of object content hits:

13

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4008

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Edition name Date
ZB-122910 Mar 14, 2023

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