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Title: Early detection of the increased risk of cardiovasculartoxicity in patients undergoing anthracycline-based CHOPregimen

Abstract:

One of the most commonly used first line regimens is CHOP protocol.It’s efficacy depends largely from doxorubicin: an anthracyclineantibiotic, responsible for marked cardiovascular toxicity. Clinicalsymptoms of doxorubicin cardiotoxicity occur late in the diseasecourse. At this stage however, the process is already non-reversible.Early diagnosis, before the eventual damage of cardiomyocytes,possible by demonstrating diastolic dysfunction, allows introducingefficient cardioprotective therapy preventing further cardiac damage.Primary and secondary targets of the work were: early identification ofpatients with high-risk of cardiotoxicity and analysis of primaryeffectiveness of cardioprotective strategies (non-pegylated liposomaldoxorubicin, cardioprotective drugs) in high risk patients. Presenteddata are consistent: NT-proBNP, spatial QRS-T angle analysis andechocardiographic assessment of diastolic dysfunction of the leftventricle allow for early detection of doxorubicin cardiotoxicity, at thereversible stage, allowing for efficient prophylaxis before irreversiblecardiomyocyte damage occurs. Primary cardioprotection withliposomal doxorubicin, in combination with the beta-adrenolytic drugsand/or ACE-inhibitor allowed for effective oncological treatment ofpatients with increased cardiovascular risk, without development ofcardiotoxic complications.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Wojciech Jurczak

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4008

Call number:

ZB-122910

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Jul 1, 2015

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4008

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ZB-122910 May 24, 2021
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