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Title: Factors regulating bronchial fibroblasts to myofibroblasts transition in patients with asthma

Abstract:

Bronchial asthma is a common chronic inflammatory airways disease. An ongoing inflammation of bronchi is accompanied by multi-step processes of remodelling which are caused by smooth muscle cells hypertrophy and subepithelial fibrosis. The latter is due to TGF-β induced fibroblasts to myofibroblasts transition. The aim of this study was to investigate the influence of the factors that may regulate TGF-β stimulated transition of human bronchial fibroblasts into myofibroblasts (FMT) and to compare the effects of their interactions in the context of asthma.The study showed a different effect of WNT activation on FMT potential on the cells derived from asthmatics and the people who were excluded from this disease.For the first time it was shown that under the action of TGF-β1 fibroblasts derived from asthmatics are capable of synthesis and secretion of CTGF.Additivity of the TGF-β1 and CTGF action in the induction process FMT was proved. The results presented in this thesis indicate that the predisposition to FMT is a permanent feature of asthmatics bronchial fibroblasts.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Marek Sanak ; Marta Michalik

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3991

Call number:

ZB-122741

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Jun 15, 2015

Number of object content hits:

40

Number of object content views in PDF format

40

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3991

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ZB-122741 May 24, 2021
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