Advanced search ?

Object

Access Limited

This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: Factors regulating bronchial fibroblasts to myofibroblasts transition in patients with asthma

Author:

Wójcik-Pszczoła, Katarzyna

Date:

2015

Type:

Praca doktorska

Abstract:

Bronchial asthma is a common chronic inflammatory airways disease. An ongoing inflammation of bronchi is accompanied by multi-step processes of remodelling which are caused by smooth muscle cells hypertrophy and subepithelial fibrosis. The latter is due to TGF-β induced fibroblasts to myofibroblasts transition. The aim of this study was to investigate the influence of the factors that may regulate TGF-β stimulated transition of human bronchial fibroblasts into myofibroblasts (FMT) and to compare the effects of their interactions in the context of asthma.The study showed a different effect of WNT activation on FMT potential on the cells derived from asthmatics and the people who were excluded from this disease.For the first time it was shown that under the action of TGF-β1 fibroblasts derived from asthmatics are capable of synthesis and secretion of CTGF.Additivity of the TGF-β1 and CTGF action in the induction process FMT was proved. The results presented in this thesis indicate that the predisposition to FMT is a permanent feature of asthmatics bronchial fibroblasts.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Wydział Lekarski

Promoter:

Sanak, Marek ; Michalik, Marta

Date issued:

2014

Identifier:

oai:dl.cm-uj.krakow.pl:3991

Call number:

ZB-122741

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

transforming growth factor type β (TGF-β) fibroblasts to myofibroblasts transition (FMT) myofibroblasts bronchial asthma connective tissue growth factor (CTGF)

Object collections:

Last modified:

Mar 16, 2023

In our library since:

Jun 15, 2015

Number of object content hits:

45

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3991

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-122741 Mar 16, 2023

Objects

Similar

Factors regulating bronchial fibroblasts to myofibroblasts transition in patients with asthma

Wójcik-Pszczoła, Katarzyna

2015
Praca doktorska

General practitioners' knowledge of the management of bronchial asthma in adults

Kryj-Radziszewska, Elżbieta

2005
Praca doktorska

Influence of dexamethasone on reactivity of peripheral blood lymphocytes in severe and refractory bronchial asthma

Jakieła, Bogdan

2008
Praca doktorska

Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland

Kasper, Łukasz

2007
Praca doktorska

Molecular and cellular mechanisms in pathophysiology of post-inflammatory cardiac fibrosis

Tkacz, Karolina

2024
Praca doktorska

The diagnostic walue of the measurment of the eicosanoids in the exhaled breath condensate after aspirin ingestion in patients with asthma bronchiale

Kiełbasa, Bogumiła

2006
Praca doktorska

The mechanisms and the role of oxidative stress in the bronchial wall in a model of asthma and bronchial hyperreactivity

Słapińska, Magdalena

2018
Praca doktorska

Polymorphisms of glutathione S-transferase P1 and M1 and production of cysteinyl leukotreienes in patients with bronchial asthma

Plutecka, Hanna

2006
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information