Object

Title: Urinary neutrophil gelatinase associated lipocalin (NGAL) as the early biomarker of diabetic kidney disease in the course of diabetes mellitus type 2

Abstract:

The study evaluates the role of measurements of neutrophil gelatinase-associated lipocalin (NGAL), and albumine and NGAL to creatine (UACR, uNGAL/uCr) markers obtained in the morning urine sample in early diagnosis of diabetic kidney disease (DKD).The study comprises 55 Type 2 diabetic patients (DM t2) aged 18 and over. The data were compared against a group of 22 non-diabetic individuals. Statistically, uNGAL/uCr is much higher in the DM t2 group. uNGAL/uCr and UACR is significantly higher in women and patients with DM t2 and cardiovascular complications. In the DM t2 group, the patient’s age and HbA1c are independent predictive factors for the concentration of uNGAL and uNGAL/uCr. uNGAL and uNGAL/uCr are clinically useful, early, changing dynamically in time, non-invasive DKD indicators, specific for renal tubule damage. The RAA blockade and statin treatment have no influence on the functioning of kidney tubules in DM t2 assessed by uNGAL and uNGAL/uCr.Leucocyturia limits the utility of uNGAL in DKD diagnosis.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; nefrologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Marek Kuźniewski

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3984

Call number:

ZB-122584

ControlNumberVIRTUA:

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Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

May 12, 2015

Number of object content hits:

583

Number of object content views in PDF format

584

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3984

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ZB-122584 May 24, 2021
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