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Title: Effects of sildenafil in patients with fixed “venous” pulmonaryhypertension

Abstract:

Aims: To assess the efficacy of sildenafil (silde) in patients withpulmonary hypertension (PH) due to heart failure with reducedejection fraction (HFREF) who were disqualified from hearttransplantation (HTX). To evaluate hemodynamic effects of nitricoxide (NO) and silde in pulmonary artery (PA) reactivity test in ptswith PH due to HFREF.Methods: 20 pts with PH due to HFREF who were previouslydisqualified from HTX because of fixed PH were enrolled to the I partof the study. Right heart catheterization (RHC) was performed withhemodynamic measurements at baseline, after inhalation of NO andthen after silde p.o. In the II part of research 17 pts received silde for 3months. At baseline and after 3 months of treatment with silde,clinical assessment, echo, cardio-pulmonary exercise test, 6-minutewalk test (6MWT) and RHC were performed.Results: In pulmonary artery reactivity test there was significantreduction of PAP, PVR, TPG, SVR after silde administrationcomparing to baseline and NO. Besides, after silde increase of CI andSatPA were observed. 13 of 17 pts completed the 3-months therapywith silde. Comparing to baseline after silde therapy there wassignificant reduction of PVR and TPG and increase of CI with nochange of PCWP and SBP. There was also improvement of peakVO2,OUES, distance in 6MWT, LVEF, PT SŚ, PT EŚ.Conclusion: Sildenafil when compared to NO is superior to reducePVR, PAP and TPG in PA reactivity test in candidates for HTX withPH due to HFREF. 3-month therapy with silde improveshemodynamic parameters, right and left ventricle performance as wellas exercise capacity in pts with PH due to HFREF.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Piotr Podolec

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3975

Call number:

ZB-122323

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Mar 26, 2015

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13

Number of object content views in PDF format

13

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3975

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ZB-122323 Jun 26, 2019
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