Object

Title: Endplate calcification, nutritional vessel occlusion and the role of proteins responsible for the elaboration of inorganic pyrophosphate in cervical disc degenerative disease

Abstract:

This study had several aims including, but not limited to (1) quantification of cell density and glycosaminoglycan (GAG) content in cervical intervertebral discs (IVDs) and endplates of varying age and degeneration grade; (2) analyzing fundamental relationships between endplate calcification, nutritional vessel occlusion and the role of proteins responsible for the elaboration of inorganic pyrophosphate in IVD degeneration.Sixty “C5 vertebrae-IVD-C6 vertebrae” complexes were excised during routine human autopsies not later than 24 hours postmortem. Further sample processing included computed microtomography, macroscopic IVD degeneration grading, histological processing, and biochemical analysis for GAG content.This study introduced several detailed 3D maps of cervical IVD and cervical endplate cell density and GAG content, which allow to correctly estimate the number of stem cells that could be injected into the IVD during degeneration stem cell treatment.This study has brought to light that, similarly to lumbar IVDs, there is a strong negative correlation between the number of endplate marrow contact channels, and both macroscopic and microscopic cervical IVD and endplate degeneration.Modulating the expression of the inorganic pyrophosphate elaborating proteins, especially ANK and TGF-β1, may be a new way to prevent the degeneration and calcification of the IVD.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

ortopedia ; patomorfologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jerzy A. Walocha

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3974

Call number:

ZB-122322

ControlNumberVIRTUA:

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Language:

pol ; eng

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 28, 2021

In our library since:

Mar 26, 2015

Number of object content hits:

178

Number of object content views in PDF format

178

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3974

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ZB-122322 May 28, 2021
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