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Title: The study of genes polymorphisms encoding paraoxonase and angiotensin convertase morphology of atherosclerotic lesions in the coronary arteries

Abstract:

The main objective of this study was to investigate the potential cor-relation between the polymorphism of genes encoding paraoxonases (PON1 – L55M and PON2 – S311C) or angiotensin convertase (ACE – I/D), and the presence and severity of atherosclerotic lesions in cor-onary angiographic image in patients with ischaemic heart disease. The study included 367 patients with stable ischaemic heart disease. The control group included 660 subjects who were not diagnosed with ischaemic heart disease. A relationship between the presence of atherosclerotic lesions in the coronary angiogram and the polymorphism in the gene coding for paraoxonase PON 2 (PON 311) was documented in this distribution. This is a relation between PON 311 gene polymorphism and the pres-ence of type C lesions in coronary arteries independently of the extent of artery narrowing. The demonstrated relation results from the impact of a single PON 311 gene polymorphism and remains statistically significant after tak-ing into account in the analysis the risk factors for atherosclerosis de-velopment. In case of atherosclerotic lesions confirmed by angiography, no rela-tionship was found between the degree of severity, localization and number of arteries with a significant narrowing and the polymorphisms in genes coding for paraoxonases and angiotensin-converting enzymes. An association was also documented between the polymorphism in genes coding for angiotensin-converting enzyme (ACE) and higher incidence of arterial hypertension and current tobacco smoking No associations were found between studied polymorphisms and dia-betes, obesity and hypercholesterolemia.Furthermore, no relationship was documented between the presence of atherosclerotic lesions in the coronary angiogram and the other exam-ined gene polymorphisms (PON 1 and PON 2 (PON 55, PON 192) encoding paraoxonases and angiotensin-converting enzymes (ACE I/D). We demonstrated a relation between some risk factors and the aspect of atherosclerotic lesions in the coronary angiogram.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Żmudka

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3954

Call number:

ZB-122326

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Sep 17, 2015

In our library since:

Mar 5, 2015

Number of object content hits:

4

Number of object content views in PDF format

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3954

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ZB-122326 Sep 17, 2015
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