Advanced search ?

Object

Download

Title: Assessment of influence of different doses of granulocyte colony stimulation factor on the efficacy of hematopoietic stem cells in the clinical observation and experimental model

Author:

Czogała, Wojciech

Date:

2014

Type:

Praca doktorska

Abstract:

Despite of good understanding of mobilization of hematopoietic stem cells it is still difficult to yield sufficient number of peripheral blood stem cells for transplantation in some patients. The objective was to assess the influence of G-CSF dose on mobilization efficacy in experimental model in different mice strains and in clinical observation in children and to find out other factors influencing the mobilization efficacy. Four mice strains were stimulated with G-CSF in different doses. White blood count, number of hematopoietic cells and clonogenity were assessed and syngenic transplantations were done. Retrospective analysis was performed in 82 patients. Collection of a minimal and optimal CD34+ cells count were assessed. There was observed that an optimal dose of G-CSF for each strai exists Different patterns of mobilization between different mice strains were observed. In the clinical analysis no influence on the mobilization efficacy of G-CSF dose, way of mobilization, type of disease and time from diagnosis to mobilization was observed. The mobilization was more efficient in boys. In multivariate analysis the influence on the mobilization efficacy of G-CSF dose was not observed. The time from diagnosis to mobilization and a type of disease were statistically significant factors and influence of sex was observed as a tendency. The mobilization was ineffective in 15%.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia ; hematologia ; immunologia ; transplantologia

Degree grantor:

Wydział Lekarski

Promoter:

Majka, Marcin

Date issued:

2013

Identifier:

oai:dl.cm-uj.krakow.pl:3932

Call number:

ZB-121451

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

G-CSF children mice hematopoietic stem cells transplantation mobilization

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 26, 2014

Number of object content hits:

120

Number of object content views in PDF format

83

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3932

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-121451 Jun 26, 2023

Objects

Similar

Assessment of influence of different doses of granulocyte colony stimulation factor on the efficacy of hematopoietic stem cells in the clinical observation and experimental model

Czogała, Wojciech

2014
Praca doktorska

Looking for potential markers of late effects of hematopoietic cell transplantation in children

Strojny, Wojciech

Praca doktorska

The influence of phytoestrogens on the reproductive system in male mice

Macura, Barbara

2009
Praca doktorska

Effect of calorie restriction on the development of atherosclerotic - molecular mechanisms

Kostogrys, Renata B.

2020
Praca doktorska

Effect of calorie restriction on the development of atherosclerotic : molecular mechanisms

Kostogrys, Renata

2020
Praca doktorska

Investigation of mechanisms of the anti-atherosclerotic effect of agmatine in apoE knockout mice

Wiśniewska, Anna

2013
Praca doktorska

Assessment of the cardiac function in mice model of dilated cardiomyopathy (Tgαq*44) and atherosclerosis (apoE/LDLR-/-) by in vivo MRI

Tyrankiewicz, Urszula

2013
Praca doktorska

The potential antiatherogenic effect of angiotensin 1-7 receptor pharmacological regulation

Totoń-Żurańska, Justyna

2012
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information