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Title: The influence of T CD8+ lymphocyte-derived suppressor factor on immune activity of murine macrophages

Abstract:

Present doctoral dissertation studies were aimed to investigate the influence of suppressive TCD8+ lymphocyte-derived exosomes on immune activity of murine macrophages (Mf).Treatment of Mf with suppressive exosomes resulted in the significant enhancement of reactive oxygen species generation; decrease of antibody-releasing splenic B cell number with the alteration of IgM/IgG titres ratio; alleviation of contact sensitivity (CHS) response in hapten-labeled Mf recipients and inhibition of CHS effector cells proliferation, while secretion of nitric oxide and cytokines by cultured exosome-treated Mf and expression of their surface markers seemed to be unaffected. Noteworthy, transferred CHS reaction was suppressed only when isolated T effector lymphocytes were treated with regulatory exosomes in the presence of Mf.Mf influenced by assayed exosomes express tolerogenic phenotype and mediate antigen-specific suppression of cellular as well as humoral immune response, probably by the release of secondary exosomes. Present results may possibly be translated to future therapy of various disorders associated with Mf enhanced inflammatory activity.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Bryniarski

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3929

Call number:

ZB-121439

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Nov 26, 2014

Number of object content hits:

17

Number of object content views in PDF format

17

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3929

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ZB-121439 Jun 26, 2019
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