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Title: The influence of T CD8+ lymphocyte-derived suppressor factor on immune activity of murine macrophages

Author:

Nazimek, Katarzyna

Date:

2014

Type:

Praca doktorska

Abstract:

Present doctoral dissertation studies were aimed to investigate the influence of suppressive TCD8+ lymphocyte-derived exosomes on immune activity of murine macrophages (Mf).Treatment of Mf with suppressive exosomes resulted in the significant enhancement of reactive oxygen species generation; decrease of antibody-releasing splenic B cell number with the alteration of IgM/IgG titres ratio; alleviation of contact sensitivity (CHS) response in hapten-labeled Mf recipients and inhibition of CHS effector cells proliferation, while secretion of nitric oxide and cytokines by cultured exosome-treated Mf and expression of their surface markers seemed to be unaffected. Noteworthy, transferred CHS reaction was suppressed only when isolated T effector lymphocytes were treated with regulatory exosomes in the presence of Mf.Mf influenced by assayed exosomes express tolerogenic phenotype and mediate antigen-specific suppression of cellular as well as humoral immune response, probably by the release of secondary exosomes. Present results may possibly be translated to future therapy of various disorders associated with Mf enhanced inflammatory activity.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia

Degree grantor:

Wydział Lekarski

Promoter:

Bryniarski, Krzysztof

Date issued:

2014

Identifier:

oai:dl.cm-uj.krakow.pl:3929

Call number:

ZB-121439

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

miRNA immune-suppression T CD8+ suppressor lymphocytes macrophages exosomes

Object collections:

Last modified:

Mar 15, 2023

In our library since:

Nov 26, 2014

Number of object content hits:

29

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3929

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Edition name Date
ZB-121439 Mar 15, 2023

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