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Title: Selected clinical and laboratory parameters and treatment outcomes in patients with metastatic clear cell renal cell carcinoma (ccRCC) undergoing sunitinib malate therapy

Abstract:

This study sought to identify predictive factors for treatment outcomes in stage IV ccRCC patients treated with sunitnib malate. It was a retrospective study, with the sample consisting of twenty-five patients treated with sunitinib malate for metastatic ccRCC between 2009 and 2013 at the Department of Oncology of the University Hospital in Cracow. I assessed sunitinib malate effects on selected clinical and laboratory indicators by comparing pretreatment values with values observed during treatment. In the second part of the study I assessed the relationship between progression-free survival times and selected clinical, laboratory, and radiological factors. I found that predictive factors for progression-free survival times included sunitinib-malate-induced hypertension, hand-foot syndrome (both assessed after the first treatment cycle), in-treatment hypothyroidism, and partial response assessed in an imaging study after the second treatment cycle. A detailed comparison between differences in these parameters in patients who had disease progression at 12.6 months and those who were progression free was carried out. I observed higher prevalence of hypertension, hand-foot syndrome, hypothyroidism, and myelotoxycity (lower neutrophil count) in the group without disease progression at the end of the studied period.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

nefrologia ; onkologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Nauk o Zdrowiu.

Promoter:

Marek Kuźniewski

Date issued:

2014

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3913

Call number:

ZB-120920

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Jul 24, 2014

Number of object content hits:

17

Number of object content views in PDF format

17

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3913

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ZB-120920 Jun 26, 2019
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