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Title: Prevalence of inherited thrombophilia polymorphisms among women with recurrent pregnancy loss

Abstract:

Background. Inherited thrombophilia might lead to recurrent pregnancy loss (RPL).Aim. The aim of this study was to estimate the prevalence of polymorphisms related with inherited thrombophilia among women with RPL in Malopolska region.Material and methods. Group of 136 women, who experienced at least 2 unexplained recurrent pregnancy loss, other possible causes of miscarriage were excluded. 106 healthy women having at least one uncomplicated pregnancy and delivery healthy children constituted a control group. Each patient were examined for: factor V Leiden (FVL), mutation M385T of factor V gene, mutation G2021A and A19911C of prothrombin gene, and C667T and A1298C of 5,10-methylenetetrahydrofoliate reductase gene (MTHFR).Results. Among patients with RPL inhabiting region of Malopolska compared to control group from occurred higher prevalence of:- FVL and mutation M385T of factor V gene, A19911G of prothrombin gene and A1298C of MTHFR gene,- Mutation A19911G of prothrombin gene in group of patients with RPL below 12 weeks of pregnancy, - Coincidence of polymorphism M385T of factor V gene and FVL in group of early and late RPL. Conclusion. 1/ TC genotype of M385T mutation carriers reveal tendency toward RPL below 7 weeks of pregnancy, 2/ Antithrombotic prophylaxis is not justified in case of mutation C667T MTHFR gene polymorphism carriership, 2/ After occurrence of two or more RPL inherited thrombophilia evaluation should be recommended

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

położnictwo ; hematologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Kazimierz Pityński

Date issued:

2013

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3910

Call number:

ZB-120652

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

May 30, 2014

Number of object content hits:

6

Number of object content views in PDF format

6

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3910

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ZB-120652 Jun 26, 2019
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