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Title: Corticospinal excitability evaluated with transcranial magneticstimulation in amyotrophic lateral sclerosis and frontotemporaldementia patients

Abstract:

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share manycharacteristics. Transcranial magnetic stimulation in ALS indicates hyperexcitabilityof the motor cortex in early disease stage, followed by reduced excitability later inthe disease course. So far there have been only few studies consideringneurophysiological assessment of motor system in FTD.The aim of the study was to evaluate corticospinal excitability in ALS and FTDpatients.The study included 33 ALS patients, 18 FTD patients and 27 controls. The analysisof TMS studies revealed reduced amplitude of motor evoked potential (MEP) inboth patients groups as compared to controls. Contralateral silent period (cSP) wassignificantly shorter in ALS patients than in control group and central motorconduction time (CMCT) was prolonged in FTD group compared to controls. WithinALS group, motor cortex excitability was substantially reduced in patients withmore severe clinical signs in the examined hand. Second neurophysiologicalevaluation performed in 18 ALS patients and 11 FTD patients demonstrated changesindicating progressive impairment of motor cortex excitability.The results of this study support the hypothesis of ALS and FTD belonging to onespectrum of neurodegenerative diseases.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Joanna Pera

Date issued:

2013

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3901

Call number:

ZB-120634

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

May 22, 2014

Number of object content hits:

22

Number of object content views in PDF format

22

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3901

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ZB-120634 May 24, 2021
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