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Ostrowska, Monika
2014
Praca doktorska
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share manycharacteristics. Transcranial magnetic stimulation in ALS indicates hyperexcitabilityof the motor cortex in early disease stage, followed by reduced excitability later inthe disease course. So far there have been only few studies consideringneurophysiological assessment of motor system in FTD.The aim of the study was to evaluate corticospinal excitability in ALS and FTDpatients.The study included 33 ALS patients, 18 FTD patients and 27 controls. The analysisof TMS studies revealed reduced amplitude of motor evoked potential (MEP) inboth patients groups as compared to controls. Contralateral silent period (cSP) wassignificantly shorter in ALS patients than in control group and central motorconduction time (CMCT) was prolonged in FTD group compared to controls. WithinALS group, motor cortex excitability was substantially reduced in patients withmore severe clinical signs in the examined hand. Second neurophysiologicalevaluation performed in 18 ALS patients and 11 FTD patients demonstrated changesindicating progressive impairment of motor cortex excitability.The results of this study support the hypothesis of ALS and FTD belonging to onespectrum of neurodegenerative diseases.
Kraków
2 - studia doktoranckie
neurologia
Wydział Lekarski
Pera, Joanna
2013
oai:dl.cm-uj.krakow.pl:3901
ZB-120634
pol
tylko w bibliotece
Mar 20, 2023
May 22, 2014
22
0
http://dl.cm-uj.krakow.pl:8080/publication/3901
RDF
OAI-PMH
Żur-Wyrozumska, Kamila
Golenia, Aleksandra
Zawiślak, Dorota
Hübner, Ilona
Kułaga, Agnieszka
Citation style: chicago-author-date iso690-author-date
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