Selected parameters of cell-mediated immune response in syphilis, with special respect to neurosyphilis - Digital Medical Library

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Title: Selected parameters of cell-mediated immune response in syphilis, with special respect to neurosyphilis

Author:

Pastuszczak, Maciej

Date:

Type:

Praca doktorska

Abstract:

Neurosyphilis may occur at every stage of syphilis. When untreated, may progress in a hidden manner for many years, leading to late neurological and psychiatric complications, which may result in permanent disability. The aim of the current study was to assess the immune response in early syphilis by measuring the levels of cytokines typical for innate immune response (TNF-α, IL-1β), Th1, Th2, Th17 and antinflammatory responses (IFN-γ, IL-4, IL-17A, IL-10, TGF-β, respectively) in cerebrospinal fluid (CSF) and serum of syphilitic patients. Significantly higher levels of CSF IFN-α, IL-17A, TNF-α, IL-10 and TGF-β were found in patients with neurosyphilis when compared to those with syphilis but not neurosyphilis. Moreover, in patients with neurosyphilis the relative advantage of antinflammatory response in CSF was found. It may cause adequate conditions for the survival of bacteria and chronic infection.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby zakaźne

Degree grantor:

Wydział Lekarski

Promoter:

Wojas-Pelc, Anna

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:3681

Call number:

Language:

Access rights:

Subject and keywords:

syphilis nervous system immunology

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2023

In our library since:

Apr 18, 2014

Number of object content hits:

679

Number of object content views in PDF format

115

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3681

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Edition name	Date
ZB-120493	Jun 26, 2023

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