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Title: The function of gonadal axis in girls with premature thelarche

Abstract:

Premature thelarche (TP) is defined as isolated breast development in girls < 8 years of age, with no other signs of puberty onset. The aim of this study was to determine the role of kisspeptin- KISS1R activation in ThP ethiopathogenesis.The study included 63 girls with TP (3 months-3,8 years), that have been divided into three groups according to the Tanner staging.: with unilateral (group A), with bilateral stage 2 (Group B), and with bilateral stage 3 (group C). The control group included healthy girls at the same age. Bone maturation, FSH, LH, TSH estradiol, testosterone, inhibin B, androstenedione, SHBG, kisspeptin levels, pelvic and breast USG were evaluated in both groups. No differences were found between the groups in the FSH, LH and estradiol levels. In patient group the uterus and the ovaries showed prepubertal sizes. Kisspeptin levels in both groups didn’t show statistically significant differences (4.8 ± 2.81 vs 3.80 ± 3.21, p = 0, 22). The kisspeptin levels in A, B, C groups were similar and didn’t depend on the Tanner stage (4,5 vs 4,93 vs 4,9, p=0,94). In patient group kisspeptin level showed a significant correlation with FCR (ang.fundo-cervical ratio), (r = 0.35, p = 0.004). Similar correlations, kisspeptin with the uterine length (r = 0.55, p = 0.018) and kisspeptin with FCR (r = 0.49, p = 0.038) were in group B. These results would suggest direct action of kisspeptin without gonadotropins and estradiol.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; pediatria

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jerzy Starzyk

Date issued:

2013

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3678

Call number:

ZB-120495

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Apr 18, 2014

Number of object content hits:

9

Number of object content views in PDF format

9

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3678

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ZB-120495 Jun 26, 2019
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