Object

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: The influence of metabolic stress factors and quercetin on mitochondrial function ofpreadipocytes

Abstract:

Nutrient overload, increased free fatty acids and glucose intake, leads tometabolic disorders. Dietary bioactives (such as quercetin) can exert various effecton cellular function. In recent years, there has been growing interest in therelationship between increased adipose tissue mass and a variety of physiologicaland pathological processes in adipocytes.The aim of the study was to investigate the influence of metabolic stressfactors (exposure to selected free fatty acids and high level of glucose) andquercetin, on mitochondrial function of human preadipocytes, as well as on towardsmature adipocytes.As an experimental model cell line Chub-S7 was selected. We havedemonstrated, that saturated fatty acids (PA and hexsacosanoic acid) decreasedintracellular ATP content, increased ROS generation and increased preadipocytedifferentiation, similarly such as AA and EPA. TTA promoted preadipocytesapoptosis. The high level of glucose stimulated ROS generation. We confirmedantioxidant properties of quercetin and showed that this flavonoid inhibition ofpreadipocyte differentiation.Data presented here shows that selected nutrients, such as free fatty acids,high level of glucose and quercetin influence on mitochondrial function anddifferentiation of human preadipocytes. These results are interesting because theseprocesses may be the target pathways for treating obesity.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Aldona Dembińska-Kieć

Date issued:

2013

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3669

Call number:

ZB-120430

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Apr 7, 2014

Number of object content hits:

8

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3669

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-120430 Jun 26, 2019
×

Citation

Citation style:

This page uses 'cookies'. More information