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Title: Pharmacotherapy of diseases from the spectrumof urticaria – an analysis of the concordancebetween recent expert guidelines, official druglicenses, and evidence for efficacy ofrecommended drugs

Abstract:

The year 2012 has seen relevant changes inPolish pharmaceutical legislation and drugreimbursement, among others limiting thereimbursement solely to indications stated in theSummaries of Product Characteristics (SPCs). Adiscrepancy with expert recommendationsbecame apparent. The aim of the study was toanalyze the concordance between up-to-date recommendations of exert bodies regarding the treatment of urticaria, scientific evidence for the effectiveness of the recommended drugs and SPCs in force in Poland. Material and methods: The analysis of Polish and international expert bodies for the treatment of urticaria published from the year 2000, along with the SPCs and clinical trials of efficacy of recommended drugs. Results: The analyses included altogether 10 published recommendations of expert bodies, 204 Summaries of Product Characteristics, 387 published results of studies on drug efficacy and 5 other legal acts. Of drugs recommended by the experts, 194 were authorized in Poland for urticaria treatment, including 158 oral preparations SGAH containing 7 active substances (bilastine, cetirizine, desloratadine, fexofenadine, levocetirizine, loratadine, rupatadine), 29 oral preparations of AH I, 4 preparations of systemic glucocorticosteroids, 2 topical glucocorticosteroid preparations and one combined preparation of human immunoglobulin with histamine. Conclusions: Considerable discrepancies exist between expert recommendations for the treatment of urticaria, the licensed use of drugs as defined in Summaries of Product Characteristics and the scientific evidence for their effectiveness.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja ; farmakologia ; dermatologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Farmaceutyczny.

Promoter:

Radosław Śpiewak

Date issued:

2013

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3660

Call number:

ZB-120305

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Mar 13, 2014

Number of object content hits:

6

Number of object content views in PDF format

6

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3660

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ZB-120305 Jun 26, 2019
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