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Title: The influence of Integra DRT on inflammation and growth factorslevels during wound healing in experimental and clinical study

Autor:

Nessler, Michał

Data:

2013

Typ:

Praca doktorska

Abstrakt:

Dermal wound healing is a dynamic process, which is regulated bycytokines and growth factors. The result of wound healing is scarformation. In order to determine regulators of process of scarformation, treatment with use of dermal regeneration template Integra® was investigated. The study hypothesis is: dermal regeneration template Integra® reduces inflammatory response in early stages of wound healing. To test the hypothesis, experimental and clinical projects were performed. In the experimental study, plasma levels of IL-4; IL-6; IL-10; TNF-α; FGF-2; GM-CSF; PDGF-BB; TGF-β1; TGF-β2 and TGF-β3 were measured in mice treated with Integra® in compare to controls. In the clinical project, plasma levels of EGF, TGF-β1, FGF-2, VEGF, IFN-α, GM-CSF, IL-4, IL-8, MMP-2, MMP-9 and hsCRP were measured in 15 pediatric patients treated with Integra® for reconstructive procedures in 4 time points. Results were compared with treatment progress and outcome.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

chirurgia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Kwiatkowski, Stanisław

Data wydania:

2013

Identyfikator:

oai:dl.cm-uj.krakow.pl:3658

Sygnatura:

ZB-120307

Język:

pol

Prawa dostępu:

nieograniczony

Subject and keywords:

wound healing inflammation Integra growthfactors cytokines

Object collections:

Last modified:

26 cze 2023

In our library since:

13 mar 2014

Number of object content hits:

837

Number of object content views in PDF format

198

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3658

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Edition name Date
ZB-120307 26 cze 2023

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