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Title: The evaluation of periodontal disease upon development of low grade systemic inflammation and atherosclerosis

Abstract:

The data provided in recent years by clinical, epidemiological and experimental studies show that periodontitis may have a significant impact on the pathogenesis and the course of a number of diseases. So far few studies have been presented describing the complex relationships between periodontitis and ischemic organ damage. There is still no unequivocal answer to the question whether a more frequently observed co-existence of periodontopathy with cardiovascular disorders is a cause- and-effect relationship. The objective of the study was to compare the intensity of the inflammatory response in patients suffering from periodontopathy and the patients with no periodontal inflammatory lesions, the group similar to the experimental group as for the sex distribution, mean age, the frequency of occurrence of other modifiable risk factors of atherosclerosis such as hypertension, dyslipidemia, hyperglycemia, obesity, smoking. Determining in periodontopathy sufferers the relationship between the degree of progression of localized tissue lesions evaluated according to the PIRI scale and the intensity of the patients’ systemic inflammatory response. Comparing the degree of progression of atherosclerosis in its clinically asymptomatic period in the experimental and control groups. Determining in both groups the frequency of occurrence of ischemic cardiovascular events. Evaluating whether periodontopathy may be a risk factor of atherosclerosis independent of other modifiable factors. The research showed that the systemic inflammatory response occurs with a statistically significantly higher intensity in periodontopathy sufferers as compared to the controls. In patients with periodontopathy a positive correlation was found between the degree of destruction of the periodontium and the concentrations of acute-phase proteins as well as the concentration of particular pro-inflammatory cytokines. The study carried out according to the chosen methodology made it also possible to assess the impact of periodontopathy on the progression of atherosclerosis. The progression of clinically asymptomatic atherosclerotic lesions was significantly higher in periodontopathy sufferers.The undergone cardiovascular events: TIA episodes, stroke, coronary artery disease, myocardial infarct, intermittent claudication in lower limbs occurred significantly more often in periodontopathy sufferers than in the controls. The analysis of the obtained results has implied that there are good reasons for periodontopathy to be treated as an independent risk factor of atherosclerosis.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

stomatologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarsko-Dentystyczny.

Promoter:

Maria Chomyszyn-Gajewska

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3642

Call number:

ZB-118787

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Nov 13, 2013

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9

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3642

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ZB-118787 Jun 26, 2019
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