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Title: Evaluation of arterial stiffness in patients with coronary atherosclerosis, cardiac syndrome X and systemic lupus erythematosus

Abstract:

Objectives: Arterial stiffness ia a risk factor of atherosclerosis and cardio-vascular complications. Systemic lupus erythematosus (SLE) is an autoimmune disease in which patients’ prognosis depends contemporarily mainly on the progression of premature atherosclerosis. Aim: To assess arterial stiffness in patients with coronary atherosclerosis (CA), cardiac syndrome X (CSX) and SLE, comparison the results with risk factors of atherosclerosis and with inflammatory markers, to determine the possible efficacy of atorvastatin on arterial stiffness in patients with SLE.Material and methods: Patients with CSX (n=44), CA (n=44), SLE (n=29). SLE patients were randomized to atorvastatin group (40 mg daily, n=14) or placebo group (n=15). Levels of cholesterol, CRP, C3c and C4 were obtained. Pulse wave velocity (PWV) was measured; patients with SLE were examined at baseline and after 1-year follow-up. Pulse wave analysis (PWA) was performed in CA and CSX group.Results: CSX patients had lower PWV (9,63±1,69 m/s) as compared to CA (11,53±2,19 m/s) and higher as compared to CG (8,07±1,03m/s). PWV in CSX and SLE (8,87±2,1 m/s) were similar. PWV increased with age and blood pressure. Diabetes mellitus and smoking increased PWV only in CA group. Inflammatory markers didn’t influence PWV. After 1-year follow-up the tendency to PWV decrease was observed in atorvastatin group (8,67±1,44 m/s vs 7,83±1,45 m/s; p=0,12), without any change in placebo group (8,84±1,79 m/s vs 8,73±1,69 m/s; p = 0,75). Conclusions: Patients with CA have the highest arterial stiffness and significantly higher peripheral and central blood pressure. SLE patients have higher arterial stiffness as compared to CG and similar as compared to CSX group. Age and arterial hypertension are independent factors that increase arterial stiffness. Diabetes mellitus and smoking increase arterial stiffness among CA patients. Inflammatory markers do not influence arterial stiffness. One-year treatment with atorvastatin 40 mg daily decreases the level of inflammatory markers in SLE patients. It decreases PWV, but there was no significance in this study, only a trend.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Piotr Podolec

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3631

Call number:

ZB-118867

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Jun 26, 2019

In our library since:

Nov 7, 2013

Number of object content hits:

15

Number of object content views in PDF format

14

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3631

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ZB-118867 Jun 26, 2019
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