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Title: Coexistence of malignant neoplasms in children with retinoblastomatreated in the Clinic of Ophthalmology and Ocular Oncology UJCM,Kraków in the period 1980-2010

Abstract:

The analysis involved 242 patients treated for the retinoblastoma in the years 1980-2010 in the Department of Ophthalmology and Ocular Oncology at the UniversityHospital in Kraków. Two groups were distinguished: a study group of 100 patients(hereditary form of retinoblastoma) and a control group of 142 patients (sporadicform of retinoblastoma).The study revealed types of secondary neoplasms that we encountered. Theincidence of cases of nonocular secondary cancers is 7% and the mortality rate inthis group is 58,8%. The cancers were: long bone sarcomas, brain tumors includingtrilateral retinoblastoma (also known as brain tumor), acute myeloid leukemia,neurofibroma, melanoma of the skin, skull sarcoma, sarcoma of soft tissue(including brain) and papillary carcinoma of the thyroid gland. The incidence ofsecondary malignancies in patients with a hereditary form of retinoblastoma is 14%and the incidence of secondary malignancies in patients with a non-inherited form ofretinoblastoma is 2,1%.The analysis indicated what were the main risk factors conducive to the formation ofsecondary life threatening tumors. Among these factors were: genetic predisposition(non-modifiable risk factor) and other modifiable factors as: external beam radiationand in some cases chemotherapy. Among other risk factors: the negative impact oftobacco smoke was noticed.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

okulistyka ; onkologia ; pediatria

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Bożena Romanowska-Dixon

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3623

Call number:

ZB-118871

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 26, 2019

In our library since:

Nov 6, 2013

Number of object content hits:

3

Number of object content views in PDF format

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3623

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ZB-118871 Jun 26, 2019
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