Advanced search ?

Object

Access Limited

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Optimalization of anti-ischemic therapy in patients with non ST- segment elevation myocardial infraction

Author:

Chyrchel, Bernadeta.

Date:

2012

Type:

Praca doktorska

Abstract:

Non ST-segment elevation acute coronary syndromes (NSTE ACS) are the major cause of hospitalization of patients with coronary artery disease (CAD). Despite improvement of treatment the short-term prognosis and long-term outcome of those patients remain poor. The administration of glycoprotein GP IIb/IIIa blockers has shown beneficial in recent clinical trials both in conservatively treated patients and after percutaneous coronary interventions (PCI). Another option for use of GP IIb/IIIa blockers with unfractionated heparin are direct thrombin inhibitiors with widely used bivalirudin. The aim of this trial was to compare the efficacy and safety of different anti-thrombotic regimens in treatment of troponin-positive NSTE ACS. One hundred patients enrolled in the trial were randomized to two treatment arms: integrillin (GP IIb/IIIa blocker) with unfractionated heparin or bivalirudin. We found statistically significant difference in the size of the infarct evaluated with enzymatic curves in favour of GP IIb/IIIa inhibitor + unfractionated heparin group. There were no differences between two groups in coronary flow after PCI in TIMI scale in infarct-related artery and the incidence of bleeding complications. The combined end-point of death, stroke, repeated myocardial infarction and bleeding complications occurred with no significant difference between the group during in-hospital, one month and six months follow-up period.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek S. Dubiel

Date issued:

2011

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3614

Call number:

ZB-118303

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

non ST-segment elevation acute coronary syndromes integrillin unfractionated heparin bivalirudin

Object collections:

Last modified:

Oct 30, 2019

In our library since:

Jul 19, 2013

Number of object content hits:

9

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3614

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-118303 Oct 30, 2019

Objects

Similar

Optimalization of anti-ischemic therapy in patients with non ST- segment elevation myocardial infraction

Chyrchel, Bernadeta.

2012
Praca doktorska

The effects of primary coronary angioplasty techniques and adjunctive pharmacotherapy on left ventricular function and myocardial perfusion

Zorkun, Cafer Sadik

2006
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information