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Title: Optimalization of anti-ischemic therapy in patients with non ST- segment elevation myocardial infraction

Author:

Chyrchel, Bernadeta.

Date:

2012

Type:

Praca doktorska

Abstract:

Non ST-segment elevation acute coronary syndromes (NSTE ACS) are the major cause of hospitalization of patients with coronary artery disease (CAD). Despite improvement of treatment the short-term prognosis and long-term outcome of those patients remain poor. The administration of glycoprotein GP IIb/IIIa blockers has shown beneficial in recent clinical trials both in conservatively treated patients and after percutaneous coronary interventions (PCI). Another option for use of GP IIb/IIIa blockers with unfractionated heparin are direct thrombin inhibitiors with widely used bivalirudin. The aim of this trial was to compare the efficacy and safety of different anti-thrombotic regimens in treatment of troponin-positive NSTE ACS. One hundred patients enrolled in the trial were randomized to two treatment arms: integrillin (GP IIb/IIIa blocker) with unfractionated heparin or bivalirudin. We found statistically significant difference in the size of the infarct evaluated with enzymatic curves in favour of GP IIb/IIIa inhibitor + unfractionated heparin group. There were no differences between two groups in coronary flow after PCI in TIMI scale in infarct-related artery and the incidence of bleeding complications. The combined end-point of death, stroke, repeated myocardial infarction and bleeding complications occurred with no significant difference between the group during in-hospital, one month and six months follow-up period.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek S. Dubiel

Date issued:

2011

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3614

Call number:

ZB-118303

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

non ST-segment elevation acute coronary syndromes integrillin unfractionated heparin bivalirudin

Object collections:

Last modified:

Oct 30, 2019

In our library since:

Jul 19, 2013

Number of object content hits:

20

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3614

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Edition name Date
ZB-118303 Oct 30, 2019

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