C-C chemokine receptor type 7 and C-C motif chemokine 19 polymorphism and angiographic patterns of coronary arteryatherosclerosis - Digital Medical Library

Skip to main menu
Skip to search engine
Skip to content
Skip to footer

Download

Description
Information

Title: C-C chemokine receptor type 7 and C-C motif chemokine 19 polymorphism and angiographic patterns of coronary arteryatherosclerosis

Author:

Date:

Type:

Praca doktorska

Abstract:

INTRODUCTION. The aim of the study was to search for the association between 9 polymorphisms in the genes for C-C chemokine receptor type 7 and C-C motif chemokine 19 and angiographic patterns of coronary artery atherosclerosis or myocardial infarction risk in Polish population. METHODS 300 patients with chronic stable coronary artery disease undergoing coronarography were genotyped by RFLP method and reverse dot blot hybridization. Single variable analysis for genotype-phenotype association involved chi-square test for additive, dominant and recessive model of inheritance, Fisher’s exact test, Cochran-Armitage trend test. Multivariate analysis involved linear regression and logistic regression RESULTS: Allele A rs17708087 frequency in patient who underwent myocardial infarction was significantly higher (75,5%) than in control group (59%, p=0,01). AA homozygotes versus other genotype carriers presented over two-fold increased risk of myocardial infarction (OR 2,13, CI 1,13-3,86). No correlation was found between CCR7, CCL19 polymorphisms and angiographic patterns of coronary artery atherosclerosis. CONCLUSIONS: The results of the study suggest that polymorphism rs17708087 may be potentially a risk factor of myocardial infarction in Polish population. Risk prediction models for coronary artery disease with rs17708087 require further research.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Korbut, Ryszard

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:3605

Call number:

Language:

Access rights:

Subject and keywords:

cardiovascular disease genetics coronary arterydisease polymorphism myocardial infarction

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2023

In our library since:

Jul 18, 2013

Number of object content hits:

528

Number of object content views in PDF format

136

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3605

Show description in RDF format:

Show description in OAI-PMH format:

Edition name	Date
ZB-118330	Jun 26, 2023

Objects

Similar

C-C chemokine receptor type 7 and C-C motif chemokine 19 polymorphism and angiographic patterns of coronary arteryatherosclerosis

Drabik, Leszek

2013

Praca doktorska

Control of cardiovascular risk factors and health-promoting behaviors in patients hospitalized due to ischemic heart disease

Pęksa, Jan Wojciech

2023

Praca doktorska

Assessment of the knowledge of risk factors and the effectiveness of stationary and online training in the prevention of cardiovascular diseases in the economically active population of the Małopolskie Voivodeship

Podolec-Szczepara, Natalia Małgorzata

2023

Praca doktorska

The search for mutations and polymorphisms in the genes formonogenic diabetes among patients with a clinical diagnosis of type 2and type 1 diabetes mellitus

Grzanka, Małgorzata

2014

Praca doktorska

Prevalence and reducing of cardiovascular risk factors in primary health care in Poland

Studziński, Krzysztof

Praca doktorska

The importance of knowledge of cardiovascular disease in Małopolska voivodeship

Waśniowska, Anna

2018

Praca doktorska

Effectiveness of education in the prevention of cardiovascular diseases in primary and secondary school students in the Małopolskie Voivodeship

Pacia, Klaudia Krystyna

Praca doktorska

Effectiveness of education in the prevention of cardiovascular diseases in patients of cardiological departments and primary health care in Małopolskie voivodship

Sarnecka, Agnieszka

2018

Praca doktorska

More

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

https://bm.cm.uj.edu.pl/en/main-page/

This page uses 'cookies'. More information