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Title: Validity of microsatelitte markers of human chromosome X inforensic medicine investigations

Abstract:

In the recent years, analysis of X-linked microsatellite markers, beside autosomal and Y-chromosomal loci, became widely used in the forensic genetics. The aim of the presented study was to carry out population analysis of twelve X-chromosomal microsatellite loci in the population sample of the southern Poland inhabitants (250 nonrelated females and males). Biostatistical analysis of obtained results and evaluation of X-STR usefulness in forensic investigations were performed as well. The tested multiplex of twelve X-linked microsatellite loci have properties indicating its usefulness in forensicgenetics investigations. These characteristics comprise in: conformity with Hardy-Weinberg equilibrium, high power of discrimination for females and males, high mean exclusion chance in “trios” and “duos”testing. Thus, X-STR markers are valuable tool in identification cases, kinship and paternity testing, some criminal cases, filogenetic and human migration testing. In the presented study, some new calculation adjustment method was proposed. This method takes into consideration haplotype frequencies observed in tested population and the possibility of linkage disequilibrium occurrence.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

genetyka

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Marek Sanak

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3572

Call number:

ZB-118331

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Oct 30, 2019

In our library since:

Jul 17, 2013

Number of object content hits:

2

Number of object content views in PDF format

2

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3572

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