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Title: Chemokine RANTES level and it’s association with endothelial dysfunction in patients with diabetes, high cardiovascular risk and cardiovascular disease

Abstract:

ObjectivesTo estimate levels of chemokine RANTES and it’s association with endothelial dysfunction in two different groups of patients: with diabetes at high cardiovascular risk and stable angina undergoing coronaroangiography.MethodologyGroup I: level of chemokine RANTES in serum was assessed in 128 consecutive patients at the average age of 56,6 (from 43 to 72 y.o.; SEM=0,56) with diabetes. Brachial flow mediated dilation (FMD) and vWillebrandt factor (vWF) were used to asses endothelial dysfunction. Measurement of Intima-media thickness (IMT) in carotid arteries was assesed to evaluate patients with and without atherosclerotic plaques. MDA levels were measured to analize RANTES association with oxydative stress. Group II: level of chemokine RANTES in serum was assessed in 62 consecutive patients at the average age of 59,3 (from 46 to 78 y.o.; SEM=0,94) with stable angina pectoris undergoing coronarography. Number of diseased coronary arteries was analized. More than 50% stenosis was considered as hemodynamically significant. Three or more arteries significantly narrowed were considered as multivessel disease. Patients were qualified to two subgroups (multivessel disease vs. less severe atherosclerosis ≤2 significantly stenosed arteries). Risk factors of coronary artery disease and inflamatory marker IL-18 were analyzed in all patients. Levels of chemokine RANTES were measured in both groups by ELISA method and expressed in ng/ml. ResultsAnalysis of risk factors of CAD showed no significant correlations in both groups of patients except of cholesterol level in group I. Significant correlations between RANTES level and endothelial dysfunction measurements (FMD (r=0.018, p<0.05) and vWF (r=0.007, p<0.01)) have been found. Results showed inverse correlation between RANTES level and in IMT assesment (r=0.012, p<0.05). MDA as marker of the oxydative stress and RANTES level showed also inverse correlation (r=0.033, p<0.05). Inverse correlation have been found between RANTES level and IL-18 (p<0.05). In group II significant correlations have been found between chemokine RANTES level and number of diseased coronary arteries (p<0.03). ConclusionsChemokine RANTES level measured in serum is a significant early marker of endothelial dysfunction. Inverse correlations between chemokine RANTES level, IMT and MDA measurements may indicate late distribution of RANTES from peripheral blood to endothelial cells in patients with later stages of atherosclerosis. Elevated RANTES level may evaluate patients to high risk group with endothelial dysfunction. Chemokine RANTES level is a significant marker of severity of coronary disease. RANTES is an early marker of inflammation, but it’s level is lower in patients with diffuse atherosclerosis. High level of chemokine RANTES in patients with stable angina pectoris may evaluate patients to high risk group.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia ; choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Żmudka

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3516

Call number:

ZB-118700

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 27, 2019

In our library since:

Jul 12, 2013

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6

Number of object content views in PDF format

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3516

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ZB-118700 Jun 27, 2019
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