Object

Title: Saccadic eye movement abnormalities in Parkinson’s disease treated by levodopa and deep brain stimulation

Abstract:

The aim of the study was to asses the types of saccadic eye movement abnormalities, the effect of both levodopa and STN DBS treatment on saccadic eye movement abnormalities in the advanced PD patients, as well as the correlation between parkinsonism symptoms and saccadic eye movement abnormalities under the applied treatment (STN DBS, levodopa) in the advanced PD patients. The study included 44 patients with idiopathic PD in the advanced stage treated with levodopa, 20 patients with a diagnosis of idiopathic PD after the deep brain stimulation procedure, and 48 healthy controls. The saccadic eye movement were recorded with a saccadometer. Patients were examined twice: in the clinical "off" and "on" condition. The control group was tested once.The results of the study confirm the previous reports on saccadic eye movement abnormalities in the advanced Parkinson’s disease in the ‘off’ condition. With the neurostimulator on, reflexive saccades in DBS patients are improved. However, voluntary saccades show little improvement. With the neurostimulator on, the saccadic parameters changes confirm automatic responses inhibition dysfunctions in PD patients. Levodopa treatment in patients treated only pharmacologically results in the opposite effect on saccades in comparison with neurostimulation turned on. Saccades get worsened with respect to the ‘off’ condition. Automatic response inhibition is reinforced. The only correlation between aggravated parkinsonism and saccadic eye movement parameters indicates how neurostimulation enhances bradykinesia and aggravates automatic response inhibition.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Andrzej Szczudlik

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3514

Call number:

ZB-117583

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Oct 28, 2019

In our library since:

Jul 12, 2013

Number of object content hits:

738

Number of object content views in PDF format

738

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3514

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-117583 Oct 28, 2019
×

Citation

Citation style:

This page uses 'cookies'. More information