The structure and function of the oxazolone-specific T-cell suppressorfactor (OX-TsF) in the murine model of contact hypersenitivity - Digital Medical Library

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Title: The structure and function of the oxazolone-specific T-cell suppressorfactor (OX-TsF) in the murine model of contact hypersenitivity

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Praca doktorska

Abstract:

The aim of this study was to define the structure and function of a suppressorfactor (OX-TsF), released by T lymphocytes and inhibiting contact hypersensitivity to oxazolone in CBA/J mice. The active compound of OX-TsF, secreted by suppressive CD8+ lymphocytes, belongs to the family of short regulatory RNAs. The function of OX-TsF is observed in both phenol-chloroform extract and chromatographically purified RNA fraction of the tested factor and shows adose-response relation. The tested factor is sensitive to RNase treatment and comprises particles of the size of 10-90 nucleotides. This work gives evidence for the exosomal mechanism of OX-TsF release by T lymphocytes into the culture supernatants. Not only do the exosomes transport the factor from regulatory to effector cells, but also provide the joint sites for the antibody fragments, produced by B1 lymphocytes and accounting for antigen specificity of the factor. OX-TsF mediates suppression of the contact hypersensitivity reaction in non-MHC-restricted way and its function may tentatively involve the apoptosis of the effector cells. It seems likely, that the observed suppressive effect in the future may beused in a therapeutic approach to the diseases caused by the impaired function of effector T cells.

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Level of degree:

2 - studia doktoranckie

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Degree grantor:

Wydział Lekarski

Promoter:

Bryniarski, Krzysztof

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Identifier:

oai:dl.cm-uj.krakow.pl:3508

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Subject and keywords:

CD8+ T suppressor cells exosomes contact hypersensitivity RNA interference TsF

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Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2023

In our library since:

May 8, 2013

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182

Number of object content views in PDF format

225

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http://dl.cm-uj.krakow.pl:8080/publication/3508

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Edition name	Date
ZB-117825	Jun 26, 2023

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