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Title: Genetic polymorphism (CYP17, CYP 19, CYP1A1 & CYP1B1) and levels of sex-steroid hormones in women of reproductive age women
Abstract:
Levels of progesterone and 17β-estradiol during menstrual cycles can be influenced by genetic and environmental factors. The aim of this dissertation was to investigate associations of polymorphisms of genes encoding enzymes involved in reproductive steroid metabolism – CYP17, CYP19, CYP1A1 and CYP1B1 with levels of progesterone and 17β-estradiol in women of reproductive age. These relationships were also controlled for the confounding effects of other factors related to levels of sex hormones in women – body mass index (BMI), percentage of body fat, physical activity, age at menarche and length of the menstrual cycle. One hundred and eighteen healthy women, aged 24 to 36 years, with regular menstrual cycles, and fulfilling other criteria for participation, took part in the study. Hormone levels were measured in daily collected saliva samples for one entire menstrual cycle. Blood samples were used for genotyping, anthropometric measurements were taken and questionnaire interviews were conducted. Results of the study showed that, after controlling for the effects of BMI, percentage body fat or physical activity, there were statistically significant associations between CYP17 and CYP19 genotypes and17β-estradiol levels. There were direct associations between CYP19 genotypes and luteal progesterone levels, and associations between CYP17, CYP1A1 and CYP1B1 genotype ; s and luteal progesterone levels, when controlling for the effects of other factors. Genotypes of certain genes were also associated with traits that may be related to levels of steroid hormones, such as menstrual cycle length, indicators of body fat, body height and age at menarche. Levels of sex-steroid hormones, especially 17β-estradiol, are important determinants of fecundity and many aspects of women's health. Therefore, from the perspective of public health it is crucial to identify factors that may affect levels of these hormones. Presented results indicate the need for studies of interactions between genetic and modifiable lifestyle factors.
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endokrynologia ; zdrowie publiczne
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Last modified:
Mar 13, 2023
In our library since:
Apr 23, 2013
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37
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http://dl.cm-uj.krakow.pl:8080/publication/3499
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| Edition name | Date |
|---|---|
| ZB-118381 | Mar 13, 2023 |
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