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Title: Plasma levels of asymmetric dimethyloarginine in the young adult offspring of patients with premature coronary artery disease

Abstract:

Family history of premature coronary artery disease (CAD) is associated with accelerated atherogenesis and excessive risk of coronary events. Endothelial dysfunction, an antecedent of atherosclerotic plaques, is largely dependent on depressed bioavailability of nitric oxide (NO).Our aim was to test the hypothesis that asymmetric dimethyl-L-arginine (ADMA), an endogenous inhibitor of nitric oxide (NO) formation, might be elevated in young offspring of patients with early-onset CAD, and could contribute to subclinical atherosclerosis.We studied 20 healthy subjects (10 men/10 women) aged 19–30 years with a parental history of documented CAD before 60 years of age, and 20 matched controls with no evidence of parental CAD. ADMA and its isomer symmetric dimethylarginine (SDMA) were determined by enzyme-linked immunosorbent assays. Averaged intima-media thickness (IMT) of the common carotid arteries was assessed by B-mode ultrasound.Demographical, clinical and biochemical characteristics of the both groups were similar. Subjects with a parental history of premature CAD exhibited similar plasma levels of ADMA and SDMA, and significantly elevated carotid IMT. The results did not substantially change upon adjustment for covariates. By multivariate analysis, parental history of premature CAD and LDL-cholesterol but not ADMA were independent positive IMT predictors.These results suggest that:- family history of premature CAD is not accompanied by elevated circulating ADMA levels in the young healthy offspring;- young healthy adults with a parental history of early-onset CAD exhibit increased carotid intima-media thickness, an index of early atherogenesis;- the pro-atherogenic effect of premature parental CAD appears independent of ADMA accumulation.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Andrzej Surdacki

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3486

Call number:

ZB-117671

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Feb 13, 2020

In our library since:

Mar 12, 2013

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3486

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ZB-117671 Feb 13, 2020
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