Object

Title: New serotonin receptors’ ligands in group of 8-aminotheophylline derivatives

Abstract:

In the theoretical part of this dissertation were presented the physiological role of 5-HT1A, 5-HT2A and 5-HT7 receptors and examples of their ligands. The known structure affinityrelationships and the published pharmacological models of the ligand-receptor interactions were also discussed. The results ofthe previous research of serotonin receptor ligands in the group of methylxanthines’ derivatives and the structure-activity relationshipin this group of compounds were presented. In the practical part the synthesis of 7-arylpiperazyinylalkyl derivatives of theophylline with differently substituted 8-aminogroup was presented. The structure of the obtained compounds was confirmed with elemental analysis, MS and 1H-NMR. The purity of these compounds was analyzed with UPLC. The final compounds were checked for their serotonin receptor affinity, what led to identification of compounds, which are 5-HT1A, 5-HT2A and 5-HT7 receptor ligands and one mixed ligand of 5-HT1A and 5-HT7 receptors. Basing on the results the structure-activity relationship in this group of compound was analyzed.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Maciej Pawłowski

Date issued:

2011

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3483

Call number:

ZB-116992

ControlNumberVIRTUA:

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Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jan 20, 2020

In our library since:

Mar 11, 2013

Number of object content hits:

1 190

Number of object content views in PDF format

1191

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3483

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ZB-16992 Jan 20, 2020
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