Object

Title: The analysis of the CD16a coding gene with respect to the B73.1/Leu11c epitope loss in patinets with selected primary immunodeficiency diseases

Abstract:

The loss of the B73.1/Leu11c epitope of CD16a (FcγRIIIa) receptor, detected by a monoclonal antibody commonly used in routine immunophenotyping of NK cells and CD14+CD16++ monocytes subpopulation, has been previously observed in several children suffering from severe recurrent infections with Herpesviridae and was associated with L48R/H polymorphism. Presented studies revealed statistically significant correlation between the B73.1/Leu11c epitope loss and primary immunodeficiencies, while it was not detected in patients with gastrointestinal malignancies or healthy controls. Also, no linkage between the defect and herpesviral infections was observed. Patients with the epitope loss did not suffer from any herpesviral infections, apart from one child with mild herpes simplex virus infection, while none of the children suffering from severe herpesviral infections had the epitope loss detected. Thus, the B73.1/Leu11c epitope loss seems not to be an isolated NK cells deficiency and its analysis is of limited use in predicting severity of clinical course of herpesviral infections. The genetic analysis of FcγRIIIa gene suggests that the epitope loss is not connected with L48R/H polymorphism, as all of analyzed individuals had FcγRIIIa-L/L coding genotype. This indicate that the change of amino acid 48 is rather a naturally occurring polymorphism that a disease-causing mutation.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Maciej Siedlar

Date issued:

2011

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3443

Call number:

ZB-116994

ControlNumberVIRTUA:

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Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 7, 2013

Number of object content hits:

392

Number of object content views in PDF format

392

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3443

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ZB-116994 May 24, 2021
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