Advanced search ?

Object

Download

Title: The analysis of the CD16a coding gene with respect to the B73.1/Leu11c epitope loss in patinets with selected primary immunodeficiency diseases

Author:

Lenart, Marzena

Date:

2012

Type:

Praca doktorska

Abstract:

The loss of the B73.1/Leu11c epitope of CD16a (FcγRIIIa) receptor, detected by a monoclonal antibody commonly used in routine immunophenotyping of NK cells and CD14+CD16++ monocytes subpopulation, has been previously observed in several children suffering from severe recurrent infections with Herpesviridae and was associated with L48R/H polymorphism. Presented studies revealed statistically significant correlation between the B73.1/Leu11c epitope loss and primary immunodeficiencies, while it was not detected in patients with gastrointestinal malignancies or healthy controls. Also, no linkage between the defect and herpesviral infections was observed. Patients with the epitope loss did not suffer from any herpesviral infections, apart from one child with mild herpes simplex virus infection, while none of the children suffering from severe herpesviral infections had the epitope loss detected. Thus, the B73.1/Leu11c epitope loss seems not to be an isolated NK cells deficiency and its analysis is of limited use in predicting severity of clinical course of herpesviral infections. The genetic analysis of FcγRIIIa gene suggests that the epitope loss is not connected with L48R/H polymorphism, as all of analyzed individuals had FcγRIIIa-L/L coding genotype. This indicate that the change of amino acid 48 is rather a naturally occurring polymorphism that a disease-causing mutation.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia

Degree grantor:

Wydział Lekarski

Promoter:

Siedlar, Maciej

Date issued:

2011

Identifier:

oai:dl.cm-uj.krakow.pl:3443

Call number:

ZB-116994

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

CD16 receptor primary immunodeficiency diseases herpesviral infection B73.1/Leu11c epitope

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Mar 7, 2013

Number of object content hits:

487

Number of object content views in PDF format

106

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3443

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-116994 Jun 26, 2023

Objects

Similar

The analysis of the CD16a coding gene with respect to the B73.1/Leu11c epitope loss in patinets with selected primary immunodeficiency diseases

Lenart, Marzena

2012
Praca doktorska

The role of CD4+CD25+Foxp3+ regulatory T cells in the patchomechanism of transient hypogammaglobulinemia of infancy

Rutkowska-Zapała, Magdalena

2013
Praca doktorska

The impact of supplementary doses of intravenous immunoglobulins preparations on the number and pro-inflammatory response of CD14+CD16++ monocytes

Strach, Magdalena

2010
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information