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Title: Selected markers of endothelial dysfunction in patients with stable angina pectoris and past Chlamydia pneumoniae infection.

Abstract:

Traditional cardiovascular risk factors do not completely explain the prevalence of atherosclerosis in patients with stable coronary artery disease. The aim of the study was to measure the inflammation process and endothelial dysfunction as major factors which initiate atherogenesis in patients with stable coronary artery disease and past Chlamydia pneumoniae infection.The study included a homogeneous group of 70 men aged 37-53 years, without traditional risk factors. The study population consisted of 40 men with stable coronary artery disease confirmed by coronary angiography, but without past myocardial infarction. Measurements were taken at about 6 months after successful PTCA. The patients continued standard pharmacological treatment (aspirin, beta-blocker, statin). The control group consisted of 30 healthy men. Subjects with obesity (BMI>30kg/m2), hypertension, diabetes mellitus, liver or kidney disease, an active inflammation, autoimmunological states, neoplasms and active smokers were excluded from the study.IgG Seropositivity for Chlamydia pneumoniae was found more frequently in patients than in healthy subjects. In contrast, the IgA seropositivity for Chlamydia pneumoniae was comparative in patientsand in the controls. The study showed significantly higher mean concentration of sICAM-1 and vWF in group with IgG anty-Ch.p. seropositivity as compared with the group without IgG antibodies against Ch.p. Furthermore, in group with IgA anty-Ch.p. seropositivity, the study showed significantly higher mean concentration sICAM-1 and vWF in comparison to the group without IgA antibodies against Ch.p. Markers of chronic inflammation in patients with stable coronary artery disease include higher levels of leukocytes, adhesion molecules ICAM-1 and VCAM-1, cytokines IL-6 and TNF-α whereas markers of endothelial injury include higher concentration of von Willebrand factor and lower concentration of thrombomodulin. In patients with stent, CCSII and with stenosis of two or three arteries were significantly elevated levels of inflammatory markers as well as antibodies against Chlamydia pneumoniae.The data suggest that past Chlamydia pneumoniae infection correlates with the degree of cytokine and integrin expression. The elevated levels of markers of inflammation and endothelial injury markers among patients with stable coronary artery disease, past Chlamydia pneumoniae infection and without traditional coronary risk factors indicate an important role of inflammation in the pathogenesis of atherosclerosis and appear to be helpful in exploring future cardiovascular events.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Władysława Kolasińska-Kloch

Date issued:

2010

Identifier:

oai:dl.cm-uj.krakow.pl:3428

Call number:

ZB-115827

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Oct 17, 2019

In our library since:

Mar 6, 2013

Number of object content hits:

6

Number of object content views in PDF format

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3428

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ZB-115827 Oct 17, 2019
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