Object

Title: Risk factors for arterial thrombosis in antiphospholipid syndrome

Abstract:

The aim of the study was to find characteristic laboratory and/or clinical features which distinguish APS patients with arterial thrombosis. We retrospectively studied 163 patients (123 women and 40 men) with APS. Patients were divided into 2 groups: first 78 subjects with arterial thrombosis and second 85 subjects with other manifestations of APS. Patients were interviewed in a retrospective manner.Significant association between arterial thrombosis and the presence of aCL IgG (p=0,036; OR=2,032) was found. The presence of LA showed no association with arterial events.There were no significant associations between any of the polymorphisms studied (GP Ia/IIa 807 C/T, GP PIA1/2 and Val/Leu 247 β2GPI) and arterial thrombosis in APS patients.We found a significant relationship with arterial thrombosis and livedo reticularis (p=0,03; OR=2,3), especially in a stroke group (OR=3,6).In an univariate analysis of classic risk factors for atherosclerosis a predictors of arterial thrombosis were: male sex (p=0,03; OR= 2,201), hypercholesterolemia (p<0,001; OR=3,69) and arterial hypertension (p=0,002; OR=2,81). Multivariate analysis showed that independent risk factors for arterial thrombosis included arterial hypertension (p=0,008; OR=1,78), hypercholesterolemia (p=0,002; OR=2,001) and present smoking (p=0,015; OR=2,048).In conclusion our results, point to an increased risk of arterial thrombosis in APS patients, who are male, show the presence of aCL IgG, suffer from arterial hypertension and/or hypercholesterolemia and are present smokers.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia ; choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek Musiał

Date issued:

2011

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3414

Call number:

ZB-116781

ControlNumberVIRTUA:

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Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Oct 21, 2019

In our library since:

Mar 6, 2013

Number of object content hits:

755

Number of object content views in PDF format

752

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3414

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ZB-116781 Oct 21, 2019
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