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Title: A diagnostic method elaborated for the evaluation of plasma monoclonal protein stability

Author:

Spólnik, Paweł

Date:

2004

Type:

Praca doktorska

Abstract:

Progressive renal dysfunction caused by the deposition of multiple myeloma-derived monoclonal proteins is, apart from infections, the commonest cause of death in patients with multiple myeloma. There has been no convenient clinical method for easy prediction of the danger. Aggregation involves basically abnormal, structurally highly unstable proteins. A method for identifying the degree of polypeptide chain packing instability could meet this problem. This work proposes a simple electrophoretic technique using Congo red and newly synthesized Congo-red derived dyes to disclose evident and discreet instabilities of myeloma proteins which may enhance the propensity to aggregate. Two basic protein instability levels, local and global, were differentiated by comparing the extent of protein loading with dye and the subsequent electrophoretic migration rate of the complexes.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia

Degree grantor:

Wydział Lekarski

Promoter:

Konieczny, Leszek

Date issued:

2004

Identifier:

oai:dl.cm-uj.krakow.pl:1304

Call number:

ZB-100463

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

protein instability Congo red monoclonal proteins

Object collections:

Last modified:

Jul 7, 2022

In our library since:

Nov 21, 2012

Number of object content hits:

10

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1304

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Edition name Date
ZB-100463 Jul 7, 2022

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