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Title: Prognostic factors in resectable pancreatic cancer : clinical and molecular variables affecting long-term survival

Author:

Sierżęga, Marek

Date:

2006

Type:

Praca doktorska

Abstract:

The aim of this study was to analyse clinical and molecular prognostics factors in resettable pancreatic cancer. One hundred and sixty-five patients underwent pancreatic resections between 1975 and 2004, including 103 (62%) males and 62 (38%) females (mean age 60.4 ±8.7 years). Of 101 tumours subjected to immunohistochemical tests, positive staining was identified for the following proteins: p53 - 71 %; Bcl-2 - 31 %; Bax - 90%; Bel-X - 79%; Bak - 25%. The presence of p53 was associated with poorer differentiation and a higher stage of the primary tumour. Bel-2 protein was related to lower staging, absence of lymph node metastases, and a higher proportion of tumours limited to the pancreas. No statistically significant correlations could be identified for Bel-X, Bax and Bak immunoreactivity and various parameters of the tumour. The median survival was 14.8 months and the 5-year survival was 14.3%. Of all analysed proteins, expression of p53 and Bel-X significantly correlated with poor survival. The following independent negative prognostic factors were identified with the Cox proportional hazards model: moderate or poor differentiation (G2/G3), metastases to regional lymph nodes, the percentage of metastatic lymph nodes > 15%, blood vessels involvement, infiltration of superior mesenteric artery or coeliac trunk, and microscopic or macroscopic residual tumour.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia

Degree grantor:

Wydział Lekarski

Promoter:

Popiela, Tadeusz

Date issued:

2005

Identifier:

oai:dl.cm-uj.krakow.pl:1246

Call number:

ZB-102669

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

prognostic factors pancreatic cancer p53 protein Bcl-2 proteins

Object collections:

Last modified:

Mar 3, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

11

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1246

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Edition name Date
ZB-102669 Mar 3, 2023

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