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Kępczyńska, Elżbieta
2005
Praca doktorska
The RM0 parameter values of N-alkyl derivatives of 1,2,3,4-tetrahydroisoquinoline, N-(2-ethylbutyryl)-N’-substituted derivatives of biuret, derivatives of barbituric acid and of 2-thiohydantoine were determined by means of reversed-phase thin-layer chromatography. Methanol was used as an organic modifier. The obtained values of chromatographic parameter of the lipophilicity, RM0, were analyzed on the basis of the compound structure. The length of carbon chain, the kind of substituent and its position in the ring, the substituent polarity and a possible electron influence were taken into consideration. In the next step, the RM0 parameter was correlated with lipophilicity parameters obtained by other methods, including computational one (log PPallas, log PCAChe, and, for some compounds, with log kIAM – the retention parameter obtained by HPLC chromatography using the immobilized artificial membrane). The linear relationships with the satisfactory correlation coefficients were received. The RM0 values of some compounds were compared to the biological data available in the literature and to other parameters. In many cases the linear correlations between the parameters were found.
Kraków
2 - studia doktoranckie
farmakologia
Wydział Farmaceutyczny
Bojarski, Jacek Tadeusz
oai:dl.cm-uj.krakow.pl:1180
ZB-101289
pol
nieograniczony
Jun 26, 2023
Nov 21, 2012
4 027
477
http://dl.cm-uj.krakow.pl:8080/publication/1180
RDF
OAI-PMH
Więckowska, Anna
Zagórska, Agnieszka
Kamiński, Krzysztof
Godyń, Justyna
Citation style: chicago-author-date iso690-author-date
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