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Title: The role of clinical and genetical risk factors in pathogenesis of diabetic retinopathy in patients with type 2 diabetes

Abstract:

The aim of the study were: to define the prevalence of diabetic retinopathy in patients with T2DM from the Polish population; to analyze the clinical features associated with this complication and to search for association between the Pro12Ala amino acid variant in the PPAR[gamma] gene, the G-A substitution in the 4852 position of the calpain 10 gene (SNP43), and two polymorphisms in protein tyrosine phosphatase-N1 (PTPN1) gene: rs3787345 (substitution T-C) and rs754118 (substitution C-T) and DR in T2DM. Materials and methods: The study group consisted of 359 T2DM. The diagnosis of DR was based on the ophthalmologic examination after the pupillary dilatation. Biochemical factors were also measured. The subjects were genotyped for markers: Pro12Ala of PPAR[gamma], SNP43 of calpain 10, rs3787345 and rs754118 of PTPN1. Results: The mean age examined patients was 60.8 +/- 9.7 years, T2DM duration: 11.2 +/- 7.0 years, body mass index: 31.3 +/- 7.4 kg/m2. Diabetic retinopathy was detected in 33.7%. Among the patients with diabetes duration below 10 years retinopathy was diagnosed in 18.3% (n=33) patients, while in the sub-group with diabetes duration between 10 and 20 years retinopathy was present in 43.7% (n=52) of T2DM individuals. In the group of patients with the longest history of diabetes (above 20 years), retinopathy was observed in 62.5% (n=35) subjects. The multivariate analysis revealed that significant predictors of diabetic retinopathy were: age at diagnosis of diabetes, duration of diabetes, HbA1c level, never-smoking status, urea serum level. The alleles and genotypes of examined markers were not associated with DR in T2DM group in non-stratified analysis. To investigate the impact of T2DM duration on development of DR, we performed additional analysis that excluded short duration DR subjects (below 50th percentile) and long-duration DR subjects (above 75th percentile), DR group: 88 individuals, mean diabetes duration 11.4±5.3 yrs, NDR: 136 individuals, mean disease duration 13.2 yrs ± 6.2, respectively. This analysis suggested that the alanine variant of Pro12Ala might be associated with decreased risk of DR (p=0.026 for alleles, p=0.04 and p=0.014 for genotypes in additive and dominant models, respectively). Conclusions: The prevalence of diabetic retinopathy was 33.7% in examined populations. We were able to confirm the role of some clinical risk factors in the pathogenesis of DR: age at diagnosis of diabetes, duration of the disease, HbA1c level, never-smoking status, urea serum level. Our data suggests that the alanine variant of the Pro12Ala polymorphism of PPAR[gamma] might be associated with decreased risk of DR in T2DM. This effect may be of indirect nature, at least in part, due to diabetic kidney disease.

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia

Degree grantor:

Wydział Lekarski

Promoter:

Maciej T. Małecki

Date issued:

2007

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1135

Call number:

ZB-105624

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tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1135

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ZB-105624 Feb 12, 2020
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