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Title: Influence of anti-inflammatory therapy on endothelial function in unstable angina

Abstract:

Background Endothelial inflammatory activation is associated with profound impairment in vasodilator endothelial function. The aim of the study was to analyze the impact of short-term anti-inflammatory therapy with high dose statin and cycklooxygenase-2 (COX-2) inhibitor on endothelial function in patients with non ST segment elevation Acute Coronary Syndromes - NSTE ACS. Methods In 30 pts with NSTE ACS and elevated C reactive protein level endothelial function was assessed by coronary Acetylcholine (Ach) test within non-culprit vessel. Quantitative coronary angiography was done at baseline and after maximum dose of Ach. Vessel response was calculated as a percent change of mean lumen diameter (% change of Mean Lumen Diameter (LD)). Then pts were randomized to three groups: A (n=11) placebo, B (n=11) 80 mg atorvastatin, C (n=8) 80 mg atorvastatin and 25 mg rofecoxib. After 7 days of therapy control test was done within the same indicatory segments. Recovery of endothelial function was calculated as difference (delta) in % changes of Mean LD between day 1 and day 7. Results At day 1 significant decrease in Mean LD between baseline and the highest dose of Ach was observed in all groups: -20 % (group A), -25 % (B) and -26 % (C). After 7 days of therapy these changes averaged -21 % (A), -15 % (B) and -10 % (C). Differences between day 1 and day 7 were -1% (A), +10 % (B), +16 % in C. Significant improvement of endothelial function was observed in group C. Conclusions NSTE ACS is associated with profound endothelial dysfunction. Short term therapy with 80 mg of atorvastatin and COX-2 inhibitor significantly improved endothelial function.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Jacek S. Dubiel

Date issued:

2006

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1098

Call number:

ZB-105377

ControlNumberVIRTUA:

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

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6

Number of object content views in PDF format

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1098

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ZB-105377 Feb 12, 2020
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