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Title: Relationship between selected polymorphisms of gene encoding p22phox subunit of the NADPH oxidase and endothelial function in patients with type 2 diabetes

Abstract:

Recent studies have identified genetic variability of p22phox NAD(P)H oxidase subunit (encoded by the CYBA gene), which is crucial to enzyme activity The present study aimed to evaluate the relationships between the incidence of C242T and A-930G gene polymorphism with endothelial function, atherosclerosis and levels of certain endothelial function markers in type 2 diabetics. 182 patients with type 2 diabetes were studied. Intima-media thickness (IMT) complex and flow mediated dilatation (FMD), NMD and plasma levels of von Willebrand factor (vWF) and malondialdehyde (MDA) were determined in relation to coding sequence (C242T) and promoter (A-930G) polymorphisms of CYBA. Polymorphism and allele distribution observed among Polish population of diabetics was similar to other Caucasian populations. No linkage disequilibrium was found between the two analyzed polymorphisms. C242T but not A-930G polymorphism was associated with endothelial function. This relationship was observed in patients with diabetes that lasted <10 years; with at least one microangiopathic complication; with coronary artery disease and increased cardiovascular risk. No relationship was found with IMT, MDA, vW in incidence of specific genotypes and allels with either investigated polymorphisms. The polymorphism C242T, of the coding sequence, but not of the promoter of p22phox gene encoding a key subunit of the NAD(P)H oxidase shows significant correlation with endothelial function in patients with type 2 diabetes. It seems thus that it might be a useful marker of the risk of endothelial dysfunction in type 2diabetic patients.

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; genetyka

Degree grantor:

Wydział Lekarski

Promoter:

Tomasz Guzik

Date issued:

2006

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1094

Call number:

ZB-105332

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

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12

Number of object content views in PDF format

12

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1094

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ZB-105332 Feb 12, 2020
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