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Title: Investigations of the antioxidant, vasoprotective and anti-platelet properties of bioflavonoids from Aronia melanocarpa

Abstract:

Recent studies show that bioflavonoids- natural polyphenols may exhibit beneficial effects in humans, especially in respect to the cardiovascular system. The aim of this study was to investigate antioxidant, anti-platelet and vasoprotective properties of polyphenols from A. melanocarpa. We studied the effects of A. melanocarpa extract on superoxide(O2-.) production in arteries and veins from patients with atherosclerosis, direct superoxide scavenging properties, effects on vascular wall tension, and the effects on platelet functions. We observed that A. melanocarpa extract has direct ROS scavenging effects at high concentrations, while at lower concentrations also decreases baseline production of O2-. in arteries and veins, significantly inhibits NADPH oxidase activity in part in NO dependent manner. A. melanocarpa extracts cause vasorelaxation and the degree of this effect seems to be correlated with NO-dependent endothelial function. Vasorelaxant effect depends on endothelium and seems to be mediated by an enhancement of the NO-cGMP pathway and partially depends on SOD activity. We observed that baseline superoxide production was greater in platelets from patients with atherosclerosis than in controls and that Aronia melanocarpa extract decreased baseline O2-. in resting platelets in this group as well as inhibited platelet aggregation . This study shows that polyphenols A. melanocarpa could play an important role in the cardioprotective therapy.

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Wydział Lekarski

Promoter:

Tomasz Guzik

Date issued:

2006

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1093

Call number:

ZB-105331

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

Number of object content hits:

6

Number of object content views in PDF format

6

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1093

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ZB-105331 Feb 12, 2020
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