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Title: The diagnostic walue of the measurment of the eicosanoids in the exhaled breath condensate after aspirin ingestion in patients with asthma bronchiale
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The main objective of this study was to establish the diagnostic value of the measurement of the eicosanoids concentration (cys-LTs, PGE2, PGF2a, 9a11ßPGFj, 8-iso-PGF2a) in the EBC using GC/MS and RIA in children and adults with asthma, and particularly AIA. We established the range of concentrations at baseline and during aspirin challenge. The eicosanoids in the EBC together with the LTE4 in the urine were measured in all groups. In addition the 9allßPGF2 was measured in the blood of the adult patients and the nitric oxide (FeNO) was measured in children. In contrast to the previously studies we employed the following methods: a common protocol for measurments EBC (Kraków, Zürich), the analytical methods that were more sensitive and specific, the analysis of mediator profiles. This study suggests it is useful to employ GC/MS and RIA in the analysis of eicosanoids in the EBC. A measurement of cys-LTs in the EBC has a diagnostic value in asthmatic children, cys-LTs levels were elevated in asthmatic children despite the treatment with inhaled corticosteroids and atopy. Any of the eicosanoids in the EBC does not discriminate adult patients with asthma from the healthy. Measurement of the LTE4 levels in urine has the best diagnostic value in AIA. Low levels of 9a11ßPGF2 in the EBC in AIA patients warrants further investigation. A significant rise in the cys-LTs levels in th ; e EBC following the aspirin challenge was noted only in AIA patients and confirms their specific role in AIA.
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Last modified:
4 lis 2022
In our library since:
21 lis 2012
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32
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All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/1085
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| Edition name | Date |
|---|---|
| ZB-105322 | 4 lis 2022 |
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