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Tytuł: Cytotoxicity of semisynthetic betulin derivatives

Autor:

Achrem-Achremowicz, Jacek

Data:

2008

Typ:

Praca doktorska

Abstrakt:

Betulin is a pentacyclic triterpene of the lupane type present as the main ingredient of the outer bark of birch trees (Betula sp.). In recent years there have been published several articles about pharmacological activity of the lupane type triterpenes concerning mainly cytotoxicity against cancer cells, antimalarial and antiinflammatory activities, etc. From the purified betulin isolated from the bark of Betula verrucosa Erh. 18 derivatives were synthesized. Identity of the compounds was confirmed on the basis of chromatographic (TLC) and spectroscopic (NMR, MS i IR) data, and theoretical values of log P were calculated, whereas for some of the compounds the values of molar lipophilicity (RM0) were determined with the use of reversed thin layer chromatography. Cytotoxicity was measured with MTT and LDH tests on NCI-H292 and ARPE-19 human cell lines. TB test was performed on murine cells B16, XC and 3T3. Most of the derivatives showed strong and often selective cytotoxic activity that was comparable to doxorubicine and colchicine. In the series of derivatives several correlations structure-activity (SAR) were found; additionally cytotoxicity of betulin derivatives measured in TB test was found to be dependant on the lipophilicity. Two models describing cytotoxicity as a function of lipophilicity were presented.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

farmakologia

Instytucja nadająca tytuł:

Wydział Farmaceutyczny

Promotor:

Janeczko, Zbigniew

Data wydania:

2007

Identyfikator:

oai:dl.cm-uj.krakow.pl:987

Sygnatura:

ZB-107454

Język:

pol

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

betulin triterpenes cytotoxicity

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

21 lis 2012

Liczba wyświetleń treści obiektu:

3 930

Liczba wyświetleń treści obiektu w formacie PDF

521

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/987

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Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-107454 26 cze 2023

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