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Title: Selected aspects of endothelial dysfunction in patients with type 2 diabetes


Introduction: One of possible mechanisms leading to the development of chronic diabetes complications is endothelial dysfunction (ED). Aim: To asses ED in patients with DM 2 and to assess the relationship between ED and diabetic retinopathy. Material: 182 patients with DM 2 with mean age 56,3 yrs. The control group included 43 healthy volunteers. Methods: We assesed endothelial function by flow-mediated dilatation (FMD) and by assessment of von Willebrand factor (vWf) and s-ICAM .Retinopathy was assessd using fundus photography; intima-media thickness of carotid artery by usg. Statistical analysis included multiple regression analysis. Results: Diabetic retinopathy was found in 39,0% of patients. Mean IMT was significantly higher and FMD lower in DM 2 patients than in control group (respectively 0,83 mm vs. 0,66 mm, p<0,00005 and 9,0% vs. 11,4%, p=0,0165). In patients with diabetic retinopathy IMT was higher than in patients without retinopathy (0,87 mm vs 0,79 mm, p=0,0001), while FMD was lower (8,38% vs 10,45%, p=0,0023). In multiple regression analysis age, insulin therapy, hypertension and retinopathy were independenet predictors for IMT value, while retinopathy and HbA1c as well as total cholesterol level for FMD. Conclusions: DM 2 patients are characterized by common occurence of ED and increased intima-media thickness. Incidence of IMT and FMD abnormalities is higher in ; diabetic retinopathy group than in patients without retinopathy. Diabetic retinopathy is an independent predictor of ED and IMT in DM 2. Patients with diabetic retinopathy need particularly intensive cardiovascular management.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; choroby układu krążenia

Degree grantor:

Wydział Lekarski


Małecki, Maciej T

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tylko w bibliotece

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Last modified:

Jul 7, 2022

In our library since:

Nov 21, 2012

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Edition name Date
ZB-107318 Jul 7, 2022


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