Title:

Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociception process in a neuropathic pain model

Author:

Wrzosek, Anna

Subject:

neuropathic pain ; tramadol ; antidepressants ; drug interactions ; isobolographic analysis

Abstract:

In neuropathic pain treatment a combined use of tramadol and antidepressants constitutes a common clinical practice. Therefore assessment of the nature of interaction between tramadol and doxepin or venlafaxine was undertaken. Research was conducted on Wistar rats. Neuropathic pain model described by Bennett (Chronic Constriction Injury) was applied. 15 days after the surgical procedure pathologic symptoms characteristic for neuropathic pain were assessed, that is: mechanical allodynia (vonFrey test) and thermal hyperalgesia (paw withdrawal latency test). Observations were carried out for 120 minutes after intraperitoneal drug administration. Nature of interaction was estimated using isobolographic analysis and indices of interaction were calculated. The obtained results confirmed effectiveness of all drugs in reduction of thermal hyperalgesia and mechanical allodynia, however doxepin was more effective than venlafaxine. Combined administration of tramadol and doxepin demonstrated synergetic action in reducing thermal hyperalgesia and additive action in reducing mechanical allodynia. Interaction between tramadol and venlafaxine was additive in both tests. Additionally, involvement of opioid mechanism was detected (by blocking of opioid receptors with naloxone) for tramadol and venlafaxine but not for doxepin. In conclusion, the experiments confirmed hypothesis that the nature of interaction between tramadol and doxepin (tricyclic antidepressive drug) is synergetic, what provides a valuable information referring to clinical practice, rationalizing administration of such drug combination.

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia ; neurologia

Degree grantor:

Wydział Lekarski

Promoter:

Jerzy Wordliczek

Date:

2007

Date issued:

2007

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-107308

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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